PDF herunterladen
Synfacts 2008(4): 0337-0337  
DOI: 10.1055/s-2008-1042888
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Nemorosone and Clusianone

Contributor(s): Philip Kocienski, Indu Dager
C. Tsukano, D. R. Siegel, S. J. Danishefsky*
Memorial Sloan-Kettering Cancer Center and Columbia University, New York, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
19. März 2008 (online)

   Lizenzen und Reprints

Significance

Nemorosone and clusianone belong to the family of acylphloroglucinols and are isolated from Clusia rosea and Clusia congestiflora, respectively. Nemorosone inhibits telomerase and ERK-1/2. They were constructed from the same intermediate, D, which was prepared by an iodonium-induced carbocyclization. This synthesis is distinguished for the use of non-conventional carbanions in several steps.