Synthesis of (±)-Clusianone

doi:10.1055/s-2008-1042889

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Synfacts 2008(4): 0331-0331
DOI: 10.1055/s-2008-1042889

Synthesis of Natural Products and Potential Drugs

Synthesis of (±)-Clusianone

Contributor(s): Philip Kocienski, Stewart Eccles
J. Qi, J. A. Porco, Jr.*
Boston University, USA

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Publication History

Publication Date:
19 March 2008 (online)

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Significance

Clusianone is isolated from the floral resin of the Clusia species. It has promising biological activity and the interesting bicyclo[3.3.0] core has made clusianone a popular target. This synthesis utilizes an alkylative dearomatization strategy to construct the bicyclic core.